https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:594 99%) was inactivated (and bound to tissue inhibitor of metalloproteinase-1). In neutrophilic asthma, more subjects had NE activity (39%) compared with both healthy control subjects (0%), subjects with eosinophilic asthma (6%), or subjects with paucigranulocytic asthma (0%, p < 0.05). There were strong and consistent positive correlations between interleukin-8, neutrophils, and proteolytic enzymes. MMP-9 was inversely correlated with NE (r = -0.93). Conclusions: Proteolytic enzyme activity in asthma is dependent on the underlying inflammatory phenotype and is differentially regulated with MMP-9 activity a feature of eosinophilic inflammation, and active NE in neutrophilic inflammation.]]> Thu 25 Jul 2013 09:10:37 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7293 Sat 24 Mar 2018 08:42:13 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:1599 Sat 24 Mar 2018 08:30:40 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:1628 99%) was inactivated (and bound to tissue inhibitor of metalloproteinase-1). In neutrophilic asthma, more subjects had NE activity (39%) compared with both healthy control subjects (0%), subjects with eosinophilic asthma (6%), or subjects with paucigranulocytic asthma (0%, p < 0.05). There were strong and consistent positive correlations between interleukin-8, neutrophils, and proteolytic enzymes. MMP-9 was inversely correlated with NE (r = –0.93). Conclusions: Proteolytic enzyme activity in asthma is dependent on the underlying inflammatory phenotype and is differentially regulated with MMP-9 activity a feature of eosinophilic inflammation, and active NE in neutrophilic inflammation.]]> Sat 24 Mar 2018 08:30:34 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:217 Sat 24 Mar 2018 07:43:01 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:4857 Sat 24 Mar 2018 07:18:49 AEDT ]]>